The Laing Art Gallery won Large Visitor Attraction of The Year, despite strong competition from the Sage and BALTIC.
Look Touch Listen and Smell, the museums’ access project, was awarded the Best Innovation in Tourism.
The project, which was rolled out at five of the eleven museums involved audio guides, maps and smelly interactives to provide a multi-sensory experience for visitors.
Neville Hails, a Discovery Museum assistant was also in the spotlight after winning an award for Outstanding Customer Service.
He has received numerous letters from visitors thanking him for helping them make the most of their day and he was congratulated for his knowledge of the museum.
Alec Coles, Tyne & Wear Museums director, said: “These awards celebrate the best in tourism in the whole of the North East.