Volunteers will need to be aged 18 or over and should be able to trace both sides of their family back for at least two generations in the same rural area. Counties covered include Cumbria, County Durham, Northumberland, Tyneside, Teesside and the Scottish Borders.
Each volunteer will be required to donate a blood sample, which will be analysed for the secrets locked within its DNA.
The results will then be subject to further analysis to show who the region's ancestors were. That information will then become one of many elements used in the forthcoming tv series to make ancient Britain relevant today.
DNA UK will air in autumn 2006 in a number of parts, each focusing on a region such as Lincolnshire and East Anglia, Kent and Sussex, Wales and the south west, Northern Ireland and of course the north east and Scotland.
Sorrel May, Associate Producer for Wag TV (the company making the series), told the 24 Hour Museum that a key element of the programmes will be in helping people connect with their ancient heritage.
"If we can say your area has a really high percentage of Viking ancentry," she said, "it kind of brings it to life."